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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDC16 All Species: 32.12
Human Site: S223 Identified Species: 47.11
UniProt: Q13042 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13042 NP_001072113.1 620 71656 S223 S E T V I P E S V D G L Q E N
Chimpanzee Pan troglodytes XP_001141335 657 75449 S260 S E T V I P E S V D G L Q E N
Rhesus Macaque Macaca mulatta XP_001089625 620 71585 S223 S E T V I P E S V N G L Q E N
Dog Lupus familis XP_848577 620 71476 S223 S E T V L P E S V D G L Q E N
Cat Felis silvestris
Mouse Mus musculus Q8R349 620 71442 S223 S E T V I P E S V D G L Q E N
Rat Rattus norvegicus NP_001019915 620 71343 S223 S E T V I P Q S V D G L Q E N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513048 324 37070
Chicken Gallus gallus NP_001006265 624 72618 S225 S E T L I P E S V N G L Q E N
Frog Xenopus laevis NP_001087093 621 71792 S221 S E T L I P E S A D G L Q E N
Zebra Danio Brachydanio rerio NP_001032466 616 70436 I224 S E M V V P D I V N G L Q D N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623316 640 73022 L233 T C S V M G V L V T D K L L G
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001203133 551 62760 L175 R S L Y Q S I L K K Y D K P V
Poplar Tree Populus trichocarpa XP_002331799 542 62607 A166 A D P L C Y E A L E C L I E N
Maize Zea mays NP_001141501 580 66070 Y203 V K A D P L C Y E A L E R L V
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_565188 543 61743 E165 K A D P L C Y E A L E C L I E
Baker's Yeast Sacchar. cerevisiae P09798 840 94974 A454 T K S N E I L A K D Y K L A D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.3 99.3 97.9 N.A. 95.4 95.9 N.A. 48.2 91.5 88.8 79.1 N.A. N.A. 49.6 N.A. 49
Protein Similarity: 100 94.3 99.6 98.5 N.A. 97.9 98 N.A. 50.1 95.8 95.8 87.9 N.A. N.A. 68.1 N.A. 66.7
P-Site Identity: 100 100 93.3 93.3 N.A. 100 93.3 N.A. 0 86.6 86.6 60 N.A. N.A. 13.3 N.A. 0
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 0 100 93.3 86.6 N.A. N.A. 33.3 N.A. 6.6
Percent
Protein Identity: 35.8 36.9 N.A. 38.2 23.8 N.A.
Protein Similarity: 52.1 54.6 N.A. 54.3 41.5 N.A.
P-Site Identity: 26.6 0 N.A. 0 6.6 N.A.
P-Site Similarity: 66.6 13.3 N.A. 6.6 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 7 7 0 0 0 0 13 13 7 0 0 0 7 0 % A
% Cys: 0 7 0 0 7 7 7 0 0 0 7 7 0 0 0 % C
% Asp: 0 7 7 7 0 0 7 0 0 44 7 7 0 7 7 % D
% Glu: 0 57 0 0 7 0 50 7 7 7 7 7 0 57 7 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 7 0 0 0 0 57 0 0 0 7 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 44 7 7 7 0 0 0 0 7 7 0 % I
% Lys: 7 13 0 0 0 0 0 0 13 7 0 13 7 0 0 % K
% Leu: 0 0 7 19 13 7 7 13 7 7 7 63 19 13 0 % L
% Met: 0 0 7 0 7 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 7 0 0 0 0 0 19 0 0 0 0 63 % N
% Pro: 0 0 7 7 7 57 0 0 0 0 0 0 0 7 0 % P
% Gln: 0 0 0 0 7 0 7 0 0 0 0 0 57 0 0 % Q
% Arg: 7 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % R
% Ser: 57 7 13 0 0 7 0 50 0 0 0 0 0 0 0 % S
% Thr: 13 0 50 0 0 0 0 0 0 7 0 0 0 0 0 % T
% Val: 7 0 0 50 7 0 7 0 57 0 0 0 0 0 13 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 7 0 7 7 7 0 0 13 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _